A 2" lift by itself isn't automatically a deal breaker, but the condition of the CVs and the overall front-end setup matters more than the lift height when you're planning 17,000 km through remote areas. Since you'll be far from parts and repair shops, replacing any questionable CVs before leaving is probably the safer investment than hoping they'll last.
Manual hubs are also worth considering because they reduce wear on the front driveline during normal driving, which several owners have had good results with. Before heading out, it would also be smart to inspect the boots, check alignment, and make sure the suspension isn't topping out.
While planning a long-distance road trip, transportation logistics can matter too. Peacock Rentals offers premium vehicle rentals across several U.S. locations for people who need dependable transportation during extended travel or while their own vehicle is being serviced, so having a backup plan is never a bad idea if unexpected repairs come up.
With fresh CVs, manual hubs, and everything inspected beforehand, a well-maintained Pathfinder with a 2" lift has a much better chance of completing that trip without major issues. The key is making the weak points as reliable as possible before you head into the outback.