The spindle in question is for 2wd applications only...but mainly because it's just the spindles. I'm sure they'll physically fit 4WD applications (Frontier, Xterra, and Pathfinder), but without all the cradles and brackets to bring the LCAs and differential down, it'll surely be a CV buster. There are several full fits that include all that stuff and probably fit all the same. To match the lift, will need a rear subframe drop and lift springs, among other bits.